Efficiency of Modulated and Dose Rate Altered Flattening Filter Free Beams in High Dose Per Fraction Radiotherapy Applications on the Survival of Prostate Cancer Cell Lines

dc.authorwosid ceylan, cemile/KLE-2854-2024
dc.authorwosid Karabey, AYSEGUL/LWI-2157-2024
dc.authorwosid Duruksu, Gökhan/F-7304-2018
dc.authorwosid Yazır, YUSUFHAN/F-7289-2018
dc.authorwosid GUNDOGDU, OZCAN/F-6064-2018
dc.contributor.author Şahin, Sevim
dc.contributor.author Ozturk, A.
dc.contributor.author Gungor, G.
dc.contributor.author Karabey, A. U.
dc.contributor.author Sahin, S.
dc.contributor.author Duruksu, G.
dc.contributor.author Gundogdu, O.
dc.contributor.other Elektrik-elektronik Mühendisliği Bölümü
dc.date.accessioned 2025-01-11T13:01:39Z
dc.date.available 2025-01-11T13:01:39Z
dc.date.issued 2021
dc.department Fenerbahçe University en_US
dc.department-temp [Ceylan, C.] Istanbul Oncol Hosp, Dept Radiat Oncol, Istanbul, Turkey; [Ozturk, A.; Duruksu, G.; Yazir, Y.] Kocaeli Univ, Fac Med, Ctr Stem Cell & Gene Therapies Res & Practice, Kocaeli, Turkey; [Gungor, G.] Acibadem Univ, Dept Radiat Oncol, Istanbul, Turkey; [Karabey, A. U.; Aksu, G.] Kocaeli Univ, Dept Radiat Oncol, Kocaeli, Turkey; [Sahin, S.] Fenerbahce Univ, Vocat Sch Hlth Serv, Istanbul, Turkey; [Gundogdu, O.] Kocaeli Univ, Dept Biomed Engn, Kocaeli, Turkey en_US
dc.description.abstract Background: The radiobiological effect of high dose rate FFF beams on the DU-145 cells was investigated with SBRT plans which have >10 Gy. Methods and Materials: To compare the radiobiological effect on DU-145 cell line four experiments designed: (1) the constant dose rate of 6 MV and 6 MV FFF with increased dose per pulse (2) the effect of dose per pulse while increasing instantaneous dose rate for 6 MV and 6 MV FFF, (3) the effect of increased average dose rate for 6 MV FFF and (4) the effect of protracted treatment time and modulation of 6 MV FFF beams. The survival fraction was counted with WST. Results: FF and FFF for 6 MV with same dose rate and treatment time has no effect on cell survival. Significant differences was observed on survival which were irradiated with 6 MV 600 MU/min and 6 MV FFF 1400 MU/min (p=0.024). There was no difference between 6 MV FFF 600 MU/min and 6 MV FFF 1400 MU/min for 10 Gy. The significant survival difference obtained for 20 Gy. The survival percentages for both 10 Gy and 20 Gy with Cyberknife were obtained higher than FFF. Conclusion: Our in-vitro study presented here show that higher dose rate and reduced treatment time might become a crucial factor for SBRT especially which has >10 Gy fraction dose. en_US
dc.description.sponsorship Kocaeli University Scientific Projects Office [2018/64] en_US
dc.description.sponsorship The authors would like to gratefully thank Kocaeli University Scientific Projects Office for financial support for the project 2018/64. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.citation 0
dc.identifier.doi 10.29242/ijrr.19.4.879
dc.identifier.endpage 889 en_US
dc.identifier.issn 2322-3243
dc.identifier.issue 4 en_US
dc.identifier.scopusquality Q4
dc.identifier.startpage 879 en_US
dc.identifier.uri https://doi.org/10.29242/ijrr.19.4.879
dc.identifier.uri https://hdl.handle.net/20.500.14627/162
dc.identifier.volume 19 en_US
dc.identifier.wos WOS:000717866000014
dc.identifier.wosquality Q4
dc.language.iso en en_US
dc.publisher Ijrr-iranian Journal Radiation Res en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject Flattening Filter Free en_US
dc.subject Cell Survival en_US
dc.subject Radiosurgery en_US
dc.subject Radiobiology en_US
dc.title Efficiency of Modulated and Dose Rate Altered Flattening Filter Free Beams in High Dose Per Fraction Radiotherapy Applications on the Survival of Prostate Cancer Cell Lines en_US
dc.type Article en_US
dc.wos.citedbyCount 0
dspace.entity.type Publication
relation.isAuthorOfPublication 137b9c99-3632-425b-a3e8-9dace6596145
relation.isAuthorOfPublication.latestForDiscovery 137b9c99-3632-425b-a3e8-9dace6596145
relation.isOrgUnitOfPublication 573efe9a-4585-4e9f-9d6e-4231d0e477bb
relation.isOrgUnitOfPublication.latestForDiscovery 573efe9a-4585-4e9f-9d6e-4231d0e477bb

Files