Efficiency of Modulated and Dose Rate Altered Flattening Filter Free Beams in High Dose Per Fraction Radiotherapy Applications on the Survival of Prostate Cancer Cell Lines

dc.contributor.author Ceylan, C.
dc.contributor.author Ozturk, A.
dc.contributor.author Gungor, G.
dc.contributor.author Karabey, A. U.
dc.contributor.author Sahin, S.
dc.contributor.author Duruksu, G.
dc.contributor.author Gundogdu, O.
dc.contributor.other Elektrik-elektronik Mühendisliği Bölümü
dc.date.accessioned 2025-01-11T13:01:39Z
dc.date.available 2025-01-11T13:01:39Z
dc.date.issued 2021
dc.description.abstract Background: The radiobiological effect of high dose rate FFF beams on the DU-145 cells was investigated with SBRT plans which have >10 Gy. Methods and Materials: To compare the radiobiological effect on DU-145 cell line four experiments designed: (1) the constant dose rate of 6 MV and 6 MV FFF with increased dose per pulse (2) the effect of dose per pulse while increasing instantaneous dose rate for 6 MV and 6 MV FFF, (3) the effect of increased average dose rate for 6 MV FFF and (4) the effect of protracted treatment time and modulation of 6 MV FFF beams. The survival fraction was counted with WST. Results: FF and FFF for 6 MV with same dose rate and treatment time has no effect on cell survival. Significant differences was observed on survival which were irradiated with 6 MV 600 MU/min and 6 MV FFF 1400 MU/min (p=0.024). There was no difference between 6 MV FFF 600 MU/min and 6 MV FFF 1400 MU/min for 10 Gy. The significant survival difference obtained for 20 Gy. The survival percentages for both 10 Gy and 20 Gy with Cyberknife were obtained higher than FFF. Conclusion: Our in-vitro study presented here show that higher dose rate and reduced treatment time might become a crucial factor for SBRT especially which has >10 Gy fraction dose. en_US
dc.description.sponsorship Kocaeli University Scientific Projects Office [2018/64] en_US
dc.description.sponsorship The authors would like to gratefully thank Kocaeli University Scientific Projects Office for financial support for the project 2018/64. en_US
dc.identifier.citation 0
dc.identifier.doi 10.29242/ijrr.19.4.879
dc.identifier.issn 2322-3243
dc.identifier.uri https://doi.org/10.29242/ijrr.19.4.879
dc.identifier.uri https://hdl.handle.net/20.500.14627/162
dc.language.iso en en_US
dc.publisher Ijrr-iranian Journal Radiation Res en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject Flattening Filter Free en_US
dc.subject Cell Survival en_US
dc.subject Radiosurgery en_US
dc.subject Radiobiology en_US
dc.title Efficiency of Modulated and Dose Rate Altered Flattening Filter Free Beams in High Dose Per Fraction Radiotherapy Applications on the Survival of Prostate Cancer Cell Lines en_US
dc.type Article en_US
dspace.entity.type Publication
gdc.author.institutional Şahin, Sevim
gdc.author.wosid ceylan, cemile/KLE-2854-2024
gdc.author.wosid Karabey, AYSEGUL/LWI-2157-2024
gdc.author.wosid Duruksu, Gökhan/F-7304-2018
gdc.author.wosid Yazır, YUSUFHAN/F-7289-2018
gdc.author.wosid GUNDOGDU, OZCAN/F-6064-2018
gdc.description.department Fenerbahçe University en_US
gdc.description.departmenttemp [Ceylan, C.] Istanbul Oncol Hosp, Dept Radiat Oncol, Istanbul, Turkey; [Ozturk, A.; Duruksu, G.; Yazir, Y.] Kocaeli Univ, Fac Med, Ctr Stem Cell & Gene Therapies Res & Practice, Kocaeli, Turkey; [Gungor, G.] Acibadem Univ, Dept Radiat Oncol, Istanbul, Turkey; [Karabey, A. U.; Aksu, G.] Kocaeli Univ, Dept Radiat Oncol, Kocaeli, Turkey; [Sahin, S.] Fenerbahce Univ, Vocat Sch Hlth Serv, Istanbul, Turkey; [Gundogdu, O.] Kocaeli Univ, Dept Biomed Engn, Kocaeli, Turkey en_US
gdc.description.endpage 889 en_US
gdc.description.issue 4 en_US
gdc.description.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
gdc.description.scopusquality Q4
gdc.description.startpage 879 en_US
gdc.description.volume 19 en_US
gdc.description.woscitationindex Science Citation Index Expanded
gdc.description.wosquality Q4
gdc.identifier.wos WOS:000717866000014
gdc.wos.citedcount 0
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