The Protective Effects Of<i> Momordica</I><i> Charantia</I> Fruit Extract in Methotrexate Induced Liver Damage in Rats

dc.authorid erdogan, omer/0000-0002-8327-7077
dc.authorid Sen, Ali/0000-0002-2144-5741
dc.authorid Cevik, Ozge/0000-0002-9325-3757
dc.authorid Ede-Pazarbasi, Seren/0000-0002-3195-4064
dc.authorid Cilingir-Kaya, Ozlem Tugce/0000-0002-2591-9174
dc.authorid Sener, Goksel/0000-0001-7444-6193
dc.authorid Ozbeyli, Dilek/0000-0002-4141-6913
dc.authorwosid Erdogan, Omer/AAW-5497-2021
dc.authorwosid özbeyli, dilek/R-8421-2019
dc.authorwosid University, Aydin Adnan/Z-2790-2019
dc.authorwosid Cevik, Ozge/F-1326-2014
dc.authorwosid Cilingir-Kaya, Ozlem Tugce/P-9830-2015
dc.contributor.author Ede Pazarbaşı, Seren
dc.contributor.author Şener, Göksel
dc.contributor.author Cevik, Ozge
dc.contributor.author Erdogan, Omer
dc.contributor.author Kaya, Ozlem Tugce Cilingir
dc.contributor.author Ede, Seren
dc.contributor.author Sener, Goksel
dc.contributor.other Eczane Hizmetleri Bölümü
dc.contributor.other Eczacılık Meslek Bilimleri Bölümü
dc.date.accessioned 2025-01-11T13:00:50Z
dc.date.available 2025-01-11T13:00:50Z
dc.date.issued 2022
dc.department Fenerbahçe University en_US
dc.department-temp [Ozbeyli, Dilek] Marmara Univ Vocat, Sch Hlth Serv, Dept Pathol Lab Tech, Istanbul, Turkey; [Sen, Ali] Marmara Univ, Fac Pharm, Dept Pharmacognosy, Istanbul, Turkey; [Cevik, Ozge; Erdogan, Omer] Adnan Menderes Univ, Dept Biochem, Fac Med, Aydin, Turkey; [Kaya, Ozlem Tugce Cilingir] Marmara Univ, Fac Med, Dept Histol & Embryol, Istanbul, Turkey; [Ede, Seren; Sener, Goksel] Fenerbahce Univ, Fac Pharm, Dept Pharmacol, Istanbul, Turkey en_US
dc.description erdogan, omer/0000-0002-8327-7077; Sen, Ali/0000-0002-2144-5741; Cevik, Ozge/0000-0002-9325-3757; Ede-Pazarbasi, Seren/0000-0002-3195-4064; Cilingir-Kaya, Ozlem Tugce/0000-0002-2591-9174; Sener, Goksel/0000-0001-7444-6193; Ozbeyli, Dilek/0000-0002-4141-6913 en_US
dc.description.abstract BACKGROUND/AIMS: Methotrexate (MTX), a cytotoxic therapeutic agent, is used for the cure of malignancies and rheumatologic disorders. However, the significant side effects of MTX limits its use. In this study, we aim to assess the hepatoprotective properties of Momordica charantia (MC) against MTX-induced liver damaged in rats.MATERIALS AND METHODS: Following one dose of MTX (20 mg/kg), the rats were given either distilled water or MC extract (300 mg/kg, po) for 5 days. After the dissection of the rats, the liver was removed to analyse tumour necrosis factor -a (TNF-a), interleukin-113 (IL-113), transforming growth factor 13 (TGF-13) and 8-hydroxy-2'-deoxy-guanosine (8-OhdG) levels and superoxide dismutase (SOD), catalase (CAT), and caspase-3 activities. The tissues were also examined histopathologically.RESULTS: The hepatic TNF-a, IL-113, TGF-13, 8-OhdG levels, and Caspase-3 activity in the MTX group were found to be significantly increased compared to the control group. However, MC extract was able to significantly decrease TNF-a, TGF-13, 8-OhdG levels, and Caspase-3 activity. Also, both the SOD and CAT activity of the MTX group decreased compared to the control group. Although only the SOD levels elevated significantly with MC treatment, the SOD and CAT activities of the MC treated group were similar to the control group. Supporting these biochemical parameters, MTX-induced histologic alterations in the liver were also ameliorated via MC treatment.CONCLUSION: Our results demonstrated that MC has a protective role against MTX-induced hepatic tissue injury by reducing apoptosis, oxidative damage, and the expression of pro-inflammatory cytokines. en_US
dc.description.woscitationindex Emerging Sources Citation Index
dc.identifier.citation 0
dc.identifier.doi 10.4274/cjms.2020.2822
dc.identifier.endpage 793 en_US
dc.identifier.issn 2149-7893
dc.identifier.issn 2536-507X
dc.identifier.issue 6 en_US
dc.identifier.scopusquality N/A
dc.identifier.startpage 787 en_US
dc.identifier.trdizinid 1170475
dc.identifier.uri https://doi.org/10.4274/cjms.2020.2822
dc.identifier.uri https://hdl.handle.net/20.500.14627/76
dc.identifier.volume 7 en_US
dc.identifier.wos WOS:000919559700013
dc.language.iso en en_US
dc.publisher Galenos Publ House en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Methotrexate en_US
dc.subject Liver en_US
dc.subject Momordica Charantia en_US
dc.subject Oxidative Stress en_US
dc.subject Inflammation en_US
dc.title The Protective Effects Of<i> Momordica</I><i> Charantia</I> Fruit Extract in Methotrexate Induced Liver Damage in Rats en_US
dc.type Article en_US
dc.wos.citedbyCount 0
dspace.entity.type Publication
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