The Impact of Interaction Between Verteporfin and Yes-Associated Protein 1/Transcriptional Coactivator With Pdz-Binding Motif-Tea Domain Pathway on the Progression of Isocitrate Dehydrogenase Wild-Type Glioblastoma

dc.authorid Ibrahim, Ismail/0000-0002-0805-8181
dc.authorid Osama, Mahmoud/0000-0003-4919-5358
dc.authorid Essibayi, Muhammed Amir/0000-0001-8325-2382
dc.authorscopusid 58010459400
dc.authorscopusid 57212085684
dc.authorscopusid 58540583900
dc.authorscopusid 58731515200
dc.authorscopusid 58540229400
dc.authorscopusid 37037278400
dc.authorwosid Ibrahim, Ismail/KLC-4059-2024
dc.authorwosid Eksi, Murat Sakir/I-3699-2012
dc.authorwosid Osama‬‏, ‪Mahmoud/AFQ-5712-2022
dc.authorwosid Essibayi, Muhammed/AAK-2800-2020
dc.contributor.author Osama, Mahmoud
dc.contributor.author Essibayi, Muhammed Amir
dc.contributor.author Osama, Mona
dc.contributor.author Ibrahim, Ismail A.
dc.contributor.author Mostafa, Mostafa Nasr
dc.contributor.author Eksi, Murat Sakir
dc.date.accessioned 2025-01-11T13:04:36Z
dc.date.available 2025-01-11T13:04:36Z
dc.date.issued 2023
dc.department Fenerbahçe University en_US
dc.department-temp [Osama, Mahmoud] Nasser Inst Res & Treatment, Dept Neurosurg, Maahad Nasser St As Sahel, Cairo 4350210, Egypt; [Osama, Mahmoud; Mostafa, Mostafa Nasr] Zagazig Univ, Fac Med, Zagazig, Egypt; [Essibayi, Muhammed Amir] Albert Einstein Coll Med, Dept Neurosurg, New York, NY USA; [Essibayi, Muhammed Amir] Mayo Clin, Dept Radiol, Rochester, MN USA; [Osama, Mona] Zagazig Univ, Fac Pharm, Zagazig, Egypt; [Ibrahim, Ismail A.] Fenerbahce Univ, Dept Phys Therapy & Rehabil, Istanbul, Turkiye; [Eksi, Murat Sakir] FSM Training & Res Hosp, Neurosurg Clin, Istanbul, Turkiye en_US
dc.description Ibrahim, Ismail/0000-0002-0805-8181; Osama, Mahmoud/0000-0003-4919-5358; Essibayi, Muhammed Amir/0000-0001-8325-2382 en_US
dc.description.abstract Verteporfin and 5-ALA are used for visualizing malignant tissue components in different body tumors and as photodynamic therapy in treating isocitrate dehydrogenase (IDH) wild-type glioblastoma (GBM). Additionally, verteporfin interferes with Yes-associated protein 1 (YAP)/Transcriptional coactivator with PDZ-binding motif - TEA domain (TAZ-TEAD) pathway, thus inhibiting the downstream effect of these oncogenes and reducing the malignant properties of GBM. Animal studies have shown verteporfin to be successful in increasing survival rates, which have led to the conduction of phase 1 and 2 clinical trials to further investigate its efficacy in treating GBM. In this article, we aimed to review the novel mechanism of verteporfin's action, the impact of its interaction with YAP/TAZ-TEAD, its effect on glioblastoma stem cells, and its role in inducing ferroptosis. en_US
dc.description.woscitationindex Emerging Sources Citation Index
dc.identifier.citation 3
dc.identifier.doi 10.1177/11795735231195760
dc.identifier.issn 1179-5735
dc.identifier.pmid 37600236
dc.identifier.scopus 2-s2.0-85168272400
dc.identifier.scopusquality Q2
dc.identifier.uri https://doi.org/10.1177/11795735231195760
dc.identifier.uri https://hdl.handle.net/20.500.14627/382
dc.identifier.volume 15 en_US
dc.identifier.wos WOS:001050016800001
dc.language.iso en en_US
dc.publisher Sage Publications Ltd en_US
dc.relation.publicationcategory Diğer en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.scopus.citedbyCount 4
dc.subject Glioblastoma en_US
dc.subject Verteporfin en_US
dc.subject Yap en_US
dc.subject Taz-Tead Pathway en_US
dc.subject Glioblastoma Stem Cells en_US
dc.subject Ferroptosis en_US
dc.title The Impact of Interaction Between Verteporfin and Yes-Associated Protein 1/Transcriptional Coactivator With Pdz-Binding Motif-Tea Domain Pathway on the Progression of Isocitrate Dehydrogenase Wild-Type Glioblastoma en_US
dc.type Review en_US
dc.wos.citedbyCount 5
dspace.entity.type Publication

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