Panax Ginseng Ameliorates Bisphenol A-Induced Liver and Kidney Damage in Rats

Abstract

Objective: Bisphenol A (BPA) is an industrial chemical that disrupts the endocrine system and impairs the oxidant-antioxidant balance. This study investigates the effects of Panax ginseng (PxG) on liver and kidney damage induced by BPA.Materials and Methods: Rats were divided into the control, control+PxG, BPA, and BPA+PxG groups. BPA (50 mg/kg) was orally administered to the BPA groups. PxG-treated groups were orally administered 100 mg/kg PxG five times per week for six weeks. At the end of the six weeks, liver and kidney tissue samples were taken for oxidative stress determination.Results: BPA administration significantly increased oxidative stress. PxG administration decreased BPA-induced oxidative stress, as evidenced by a reduction in lipid peroxidation and restoration of antioxidant enzyme activity in liver and kidney tissues.Conclusion: PxG exhibits hepatoprotective and nephroprotective effects. Considering the widespread environmental exposure to BPA, PxG may represent a promising therapeutic agent for preventing BPA- induced hepatic and renal injury.