A Systematic Review and Meta-Analysis of Molecular Characteristics on Colistin Resistance of <i>acinetobacter Baumannii</I>

dc.authorid Kahraman Kilbas, Elmas Pinar/0000-0003-1348-625X
dc.authorid CIFTCI, IHSAN HAKKI/0000-0002-9812-134X
dc.authorscopusid 8669926200
dc.authorscopusid 57226442170
dc.authorscopusid 57199149860
dc.authorwosid Ciftci, Ihsan/HTP-7328-2023
dc.authorwosid Kılbaş, Elmas/HRC-3339-2023
dc.contributor.author Kahraman Kılbaş, Elmas Pınar
dc.contributor.author Kilbas, Elmas Pinar Kahraman
dc.contributor.author Kilbas, Imdat
dc.contributor.other Tıbbi Hizmetler ve Teknikler Bölümü
dc.date.accessioned 2025-01-11T13:03:22Z
dc.date.available 2025-01-11T13:03:22Z
dc.date.issued 2024
dc.department Fenerbahçe University en_US
dc.department-temp [Ciftci, Ihsan Hakki] Sakarya Univ, Fac Med, Dept Med Microbiol, TR-54100 Sakarya, Turkiye; [Kilbas, Elmas Pinar Kahraman] Fenerbahce Univ, Hlth Serv Vocat Sch, Dept Med Lab Tech, TR-34758 Istanbul, Turkiye; [Kilbas, Imdat] Istanbul Univ, Inst Hlth Sci, Med Microbiol Doctorate Program, TR-34093 Istanbul, Turkiye en_US
dc.description Kahraman Kilbas, Elmas Pinar/0000-0003-1348-625X; CIFTCI, IHSAN HAKKI/0000-0002-9812-134X en_US
dc.description.abstract Background: This study aimed to determine the molecular epidemiology of colistin-resistant A. baumannii in the last ten years and the frequency of gene regions related to pathogenesis, to compare the methods used to detect genes, and to confirm colistin resistance. Methods: This meta-analysis study was conducted under Preferred Reporting Items for Systematic Reviews and Meta-Analysis Guidelines. In the meta-analysis, research articles published in English and Turkish in electronic databases between January 2012 and November 2023 were examined. International Business Machines (IBM) Statistical Package for the Social Sciences (SPSS) Statistics for Macbook (Version 25.0. Armonk, NY, USA) was used for statistical analysis. The Comprehensive Meta-Analysis (CMA) (Version 3.0. Biostat, NJ, USA) program was used for heterogeneity assessment in the articles included in the meta-analysis. Results: After evaluating the studies according to the elimination criteria, 18 original articles were included. Among colistin-resistant strains, blaOXA-51 positivity was 243 (19.61%), blaOXA-23 was 113 (9.12%), blaOXA-58 was 7 (0.56%), blaOXA-143 was 15 (1.21%), and blaOXA-72 was seen in two (0.16%) strains. The positivity rates of pmrA, pmrB, and pmrC were found to be 22 (1.77%), 26 (2.09%), and 6 (0.48%). The mcr-1 rate was found to be 91 (7.34%), the mcr-2 rate was 78 (6.29%), and the mcr-3 rate was 82 (6.61%). Conclusions: The colistin resistance rate in our study was found to be high. However, only some research articles report and/or investigate more than one resistance gene together. Additionally, it may be challenging to explain colistin resistance solely by expressing resistance genes without discussing accompanying components such as efflux pumps, virulence factors, etc. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.citation 0
dc.identifier.doi 10.3390/diagnostics14222599
dc.identifier.issn 2075-4418
dc.identifier.issue 22 en_US
dc.identifier.pmid 39594265
dc.identifier.scopus 2-s2.0-85210143007
dc.identifier.scopusquality Q2
dc.identifier.uri https://doi.org/10.3390/diagnostics14222599
dc.identifier.uri https://hdl.handle.net/20.500.14627/265
dc.identifier.volume 14 en_US
dc.identifier.wos WOS:001364317100001
dc.identifier.wosquality Q2
dc.language.iso en en_US
dc.publisher Mdpi en_US
dc.relation.publicationcategory Diğer en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.scopus.citedbyCount 1
dc.subject <Italic>Acinetobacter Baumannii</Italic> en_US
dc.subject Colistin Resistance en_US
dc.subject Mcr en_US
dc.subject Pmr en_US
dc.subject Oxa en_US
dc.title A Systematic Review and Meta-Analysis of Molecular Characteristics on Colistin Resistance of <i>acinetobacter Baumannii</I> en_US
dc.type Review en_US
dc.wos.citedbyCount 1
dspace.entity.type Publication
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