The Effects of Chard Extract Against Streptozotocin-Induced Erectile Dysfunction in Rats

dc.contributor.author Şener, Göksel
dc.contributor.author Sacan, Ozlem
dc.contributor.author Kabasakal, Levent
dc.contributor.author Cetinel, Sule
dc.contributor.author Kadihasanoglu, Mustafa
dc.contributor.author Kendirci, Muammer
dc.contributor.author Sener, Goksel
dc.contributor.other Eczacılık Meslek Bilimleri Bölümü
dc.date.accessioned 2025-01-11T13:03:12Z
dc.date.available 2025-01-11T13:03:12Z
dc.date.issued 2024
dc.department Fenerbahçe University en_US
dc.department-temp [Aydin, Mustafa] Univ Hlth Sci, Samsun Training & Res Hosp, Dept Urol, Samsun, Turkiye; [Sacan, Ozlem; Yanardag, Refiye] Istanbul Univ Cerrahpasa, Fac Engn, Dept Chem, Istanbul, Turkiye; [Kabasakal, Levent; Ipci, Yesim] Marmara Univ, Fac Pharm, Dept Pharmacol, Istanbul, Turkiye; [Cetinel, Sule] Marmara Univ, Sch Med, Dept Histol & Embriol, Istanbul, Turkiye; [Kadihasanoglu, Mustafa] Univ Hlth Sci, Istanbul Training & Res Hosp, Dept Urol, Istanbul, Turkiye; [Kendirci, Muammer] Istinye Univ, Liv Hosp Ulus, Fac Med, Dept Urol, Istanbul, Turkiye; [Sener, Goksel] Fenerbahce Univ, Fac Pharm, Dept Pharmacol, Istanbul, Turkiye en_US
dc.description.abstract Background and Aims: To analyze the potential therapeutic effects of chard against streptozotocin (STZ) -induced erectile dysfunction (ED) and oxidative damage in the corpus cavernousum in rats. Materials and Methods: In this study, Sprague-Dawley rats (250-300g) were allocated into groups as follows: control, diabetic, diabetic + chard, and diabetic + insulin. In order to induce diabetes, rats were given 65 mg/kg intraperitoneal streptozotocin. Chard extract was given orally at a dose 2 g/kg for 45 days beginning on 15 th days. Sixty days after STZ injection, intracavernosal pressure (ICP) was measured and rats were decapitated. Blood samples were obtained for glucose, asymmetric dimethylarginine (ADMA)levels, and lactate dehydrogenase (LDH) activity while cavernous tissues were taken to analyze luminol and lucigenin chemiluminescence (CL), malondialdehyde and glutathione and along with histological analysis. Results: The results revealed that diabetes caused significant decreases in cavernosal tissue glutathione levels, while luminol and lucigenin CL, and malondialdehyde levels were significantly elevated. Plasma glucose, ADMA levels, and LDH activity were also found to be increased in diabetic group. On the other hand, both chard extract and insulin treatment reversed these biochemical parameters significantly. Furthermore, it was found that the ICP value examined for evaluating erectile functions were lower in the diabetic group, but increased in both treatment groups which were similar to the control values. Conclusion: According to our results, chard extract, similar to insulin, reduced diabetes -induced oxidative damage in cavernosal tissue and protected erectile functions. This effects may be attributed its hypoglycemic and antioxidant properties. en_US
dc.description.woscitationindex Emerging Sources Citation Index
dc.identifier.citation 0
dc.identifier.doi 10.26650/IstanbulJPharm.2024.1070319
dc.identifier.endpage 19 en_US
dc.identifier.issn 2587-2087
dc.identifier.issue 1 en_US
dc.identifier.scopusquality N/A
dc.identifier.startpage 12 en_US
dc.identifier.trdizinid 1279959
dc.identifier.uri https://doi.org/10.26650/IstanbulJPharm.2024.1070319
dc.identifier.uri https://hdl.handle.net/20.500.14627/231
dc.identifier.volume 54 en_US
dc.identifier.wos WOS:001216536800001
dc.language.iso en en_US
dc.publisher Istanbul Univ, Fac Pharmacy en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject Chard Extract en_US
dc.subject Diabetes Mellitus en_US
dc.subject Erectile Dysfunction en_US
dc.subject Oxidative Damage en_US
dc.title The Effects of Chard Extract Against Streptozotocin-Induced Erectile Dysfunction in Rats en_US
dc.type Article en_US
dc.wos.citedbyCount 0
dspace.entity.type Publication
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