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Öztürk, Ayşe
Öztürk, Ayşe
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Öztürk, A.
Job Title
Doktor Öğretim
Email Address
ayse.ozturk@fbu.edu.tr
Main Affiliation
Mimarlık Bölümü
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Website
ORCID ID
0009-0007-9893-554X
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Ceylan, C.
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Duruksu, G.
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Gündoğdu, Ö.
1
Güngör, G.
1
Karabey, A.U.
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Cell Survival
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Flattening Filter Free
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Radiobiology
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Radiosurgery
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2021
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Article
Efficiency of Modulated and Dose Rate Altered Flattening Filter Free Beams in High Dose Per Fraction Radiotherapy Applications on the Survival of Prostate Cancer Cell Lines
(
Novin Medical Radiation Institute
,
2021
)
Öztürk, Ayşe
;
Şahin, Sevim
;
Güngör, G.
;
Karabey, A.U.
;
Şahin, S.
;
Duruksu, G.
;
Gündoğdu, Ö.
;
Mimarlık Bölümü
;
Elektrik-elektronik Mühendisliği Bölümü
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Background: The radiobiological effect of high dose rate FFF beams on the DU-145 cells was investigated with SBRT plans which have >10 Gy. Methods and Materials: To compare the radiobiological effect on DU-145 cell line four experiments designed: (1) the constant dose rate of 6 MV and 6 MV FFF with increased dose per pulse (2) the effect of dose per pulse while increasing instantaneous dose rate for 6 MV and 6 MV FFF, (3) the effect of increased average dose rate for 6 MV FFF and (4) the effect of protracted treatment time and modulation of 6 MV FFF beams. The survival fraction was counted with WST. Results: FF and FFF for 6 MV with same dose rate and treatment time has no effect on cell survival. Significant differences was observed on survival which were irradiated with 6 MV 600 MU/min and 6 MV FFF 1400 MU/min (p=0.024). There was no difference between 6 MV FFF 600 MU/min and 6 MV FFF 1400 MU/min for 10 Gy. The significant survival difference obtained for 20 Gy. The survival percentages for both 10 Gy and 20 Gy with Cyberknife were obtained higher than FFF. Conclusion: Our in-vitro study presented here show that higher dose rate and reduced treatment time might become a crucial factor for SBRT especially which has >10 Gy fraction dose. © 2021 Novin Medical Radiation Institute. All rights reserved.
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