Kılbaş, İmdat
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Dr. Öğr. Üyesi
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imdat.kilbas@fbu.edu.tr
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Diş Protez Teknolojisi Programı
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4 results
Scholarly Output Search Results
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Article Citation - Scopus: 1A Systematic Review And Meta-analysis Of The Prevalence, Risk Factors, Agents And Laboratory Diagnosis Of Vulvovaginal Candidiasis İn Türkiye;(Refik Saydam National Public Health Agency (RSNPHA), 2024) Kilbaş, İ.; Kilbaş, E.P.K.; Çİftçİ, İ.H.Objective: Vulvovaginal candidiasis (VVC) is the most common superficial mycosis among women, and it is estimated that 75% of women experience at least one in their lifetime, and about 40-50% have a second exposure. This study aims to determine the prevalence, risk factors, etiological factors and laboratory diagnosis of VVC in Türkiye. Methods: In the study, original scientific articles for the reporting of VVC epidemiological features published in English and Turkish languages in national and international databases (PubMed, Embase, Scopus, Google Scholar, Web of Science and Turkish Medline) between January 1995 and December 2021 were searched. Electronic databases were searched using various combinations of “vaginal yeast infection”, “vaginal candidiasis”, “vulvovaginal candidiasis Turkey”, “candidal vaginitis”, “Candida vaginitis”, “vaginal candidosis”, “Candida species”, “epidemiology” key terms. Results: The mean prevalence of VVC in adult women was found to be 57.91% in all of the 28 included studies, and 68.21% in the 2-18 age group. Considering the causative distribution, the most common Candida albicans (54.76%), Candida glabrata (24.04%), other Candida species (12.29%), Candida krusei (3.68%), Candida kefyr (3.37%), and Candida tropicalis (2.07%) positivity has been reported. In the included studies, the most common predisposing factors of the patients were pregnancy (35.71%) and diabetes (35.71%). When the articles were examined according to the year they were published and the provinces, it was seen that the prevalence of Candida did not differ significantly (p>0.05). In the studies, VITEK®2 (bioMérieux, Marcy l’Etoile, France) automatic identification system (15), Germ tube (7) and CHROMagar (7) diagnostic methods were used to identify strains. As a result of the meta analysis, it was determined that there was a high level of heterogeneity among studies (I2=95.28). Conclusion: As a result of our meta-analysis study, the prevalence of VVC was found to be high in women and children in Turkey. In addition, it was determined that non-albicans species increased in the etiology of VVK. It has been observed that the incidence of C. glabrata species in the etiology of VVC has increased since 1999. Considering that VVK infection increases the susceptibility to other sexually transmitted diseases, as well as the risk of preterm birth and congenital cutaneous candidiasis in pregnant women, it is essential to raise awareness of patients on issues such as treatment follow-up and protection from the disease. © (2024), (Refik Saydam National Public Health Agency (RSNPHA)). All Rights Reserved.Article Acinetobacter baumannii Suşlarında Serum Proteinlerinin in-vitro Antibiyotik Sinerji Testleri Üzerine Etkisi(2026) Kılbaş, Elmas Pınar Kahraman; Kilbaş, İmdat; Çıftcı, Ihsan HakkıObjective: Antimicrobial resistance poses a critical threat to global health and significantly compromises the effectiveness of empirical antibiotic therapy. Therefore, the accuracy and reliability of antimicrobial susceptibility testing are of paramount importance. The aim of this study was to evaluate the in vitro activity of Acinetobacter baumannii strains against carbapenem group antibiotics and ampicillin-sulbactam combinations and the synergistic effects of these combinations in the presence of fetal bovine serum (FBS). Material and Method: A total of 18 multidrug-resistant and two standard A. baumannii strains were included in the study. These strains were resistant to the carbapenem antibiotics meropenem (MEM), imipenem (IPM), and doripenem (DOR); the aminoglycosides gentamicin and tobramycin; and the quinolones ciprofloxacin and levofloxacin. Minimum inhibitory concentration (MIC) and fractional inhibitory concentration index (FICI) tests were performed in accordance with the Clinical and Laboratory Standards Institute (CLSI) guidelines. Synergy analyses were conducted using the broth microdilution method, and tests were repeated following adaptation in FBS-supplemented medium. Results: Resistance rates among the A. baumannii isolates were found to be 95% for IPM and MEM, 90% for DOR, and 85% for ampicillin-sulbactam (SAM). MIC50/MIC90 values were calculated as follows: SAM: 8/32 μg/mL, IPM: 32/32 μg/mL, MEM: 32/32 μg/mL, and DOR: 32/32 μg/mL. Among the combination therapies, SAM-DOR demonstrated the highest efficacy, exhibiting 15% synergy and 45% partial synergy. An increase in the MIC values of the antibiotics was observed in the presence of fetal bovine serum. Conclusion: As a result of the study, although some antibiotic combinations showed synergistic effects, it was concluded that the evaluation of antibiotic combinations requires test protocols that take into account not only microbiological data but also host factors.Article Pandeminin Gölgesinde Geçen 2 Yıl: Sorularla Covıd-19(2022) Kilbaş, İmdat; Kılbaş, Elmas Pınar Kahraman; Çıftcı, Ihsan HakkıCOVID-19 salgını ilk olarak 2019 yılında Çin’de başlamıştır. SARS-CoV-2 virüsünün neden olduğu bu hastalık kısa süre içinde bir pandemi haline gelmiştir. COVID-19’un beraberinde getirdiği toplumsal problemler, bu hastalıkla ilgili temel ve kanıta dayalı bilgilere yönelik çok sayıda soru gündeme getirmiştir. COVID-19 ile ilgili aşı ve tedavi çalışmaları artan hızda devam etmektedir. Bu makalede, COVID-19’un virolojisi, immünolojisi, tanısı, komorbiditeleri, epidemiyolojisi, tedavisi ve aşı geliştirme çalışmaları hakkında bazı sorular cevaplanmıştır.Review Molecular Characterization of Resistance and Virulence Genes in Enterococcus Faecium Strains Isolated Between 2000-2021; Systematic Review(Bilimsel Tip Yayinevi, 2022) Kahraman Kilbas, Elmas Pinar; Kilbas, Imdat; Ciftci, Ihsan Hakki; Kılbaş, Elmas Pınar KahramanIntroduction: The spread of Vancomycin-Resistant Enterococci (VRE) is a major threat in healthcare institutions, especially for patients in the risk group. The aim of this study is to reveal the antibiotic resistance genes, virulence genes and other accompanying factors detected in vancomycin resistant Enterococcus faecium strains isolated from various clinical specimens in different parts of Turkiye. Material and Methods: For this purpose, a systematic search was carried out using different electronic databases between January 2000 and September 2021. A total of 17 studies were evaluated within the scope of systematic review. Results: The vanA gene was detected the most between the years 2000-2007, and no statistically significant difference was found according to the years. The prevalence of the vanB gene was highest between 2008 and 2013, and no statistical difference was found according to the years (p> 0.05). The vanA gene was mostly detected in Eastern Anatolia, Black Sea, Mediterranean and Aegean, vanB Central Anatolia and Southeastern Anatolia regions. No reports related to the vanC gene were found. Since all strains were E. faecium in our study, it is an expected finding that the vanC gene region was never reported. The esp and hyl gene between 2014-2021. Conclusion: The prevalence of resistance and virulence genes among bacteria is a matter of great concern, limiting treatment options. In particular, effective measures should be taken to prevent healthcare-associated VRE infections, and each institution should report its own resistance data.