Bardakcı, Hilal

Profile Picture
Profile URL
https://hdl.handle.net/20.500.14627/472
Name Variants
Bardakci, Hilal
Bardakci, Hilal
Job Title
Doçent
Email Address
hilal.bardakci@fbu.edu.tr
Main Affiliation
Eczacılık Meslek Bilimleri Bölümü
Eczacılık Meslek Bilimleri Bölümü
Eczacılık Meslek Bilimleri Bölümü
Status
Website
ORCID ID
0000-0001-8799-6565
Scopus Author ID
53663201500
Turkish CoHE Profile ID
Google Scholar ID
eIfzj7kAAAAJ
WoS Researcher ID
AAH-9377-2019

Sustainable Development Goals

SDG data is not available
Scholarly Output

2

Articles

1

Citation Count

7

Supervised Theses

0

Filters

20232
Reset filters

Settings

Scholarly Output Search Results

Now showing 1 - 2 of 2
  • Thumbnail Image
    Article
    Citation - WoS: 10
    in Vitro Assessment of Dermatological Activity Potential Of Achillea Clypeolata Sm. in H2o2-Treated Human Dermal Fibroblasts
    (Elsevier, 2023) Barak, Timur Hakan; Kurt-Celep, Inci; Dilek-Tepe, Hafize; Bardakci, Hilal; Akaydin, Galip; Yesilada, Erdem; Celep, Engin; Eczacılık Meslek Bilimleri Bölümü
    Members of Achilllea L. genus are widely used against dermatological disorders in traditional medicine. An increasing number of experimental studies indicated that these species are an important source of ailments against such conditions. Besides, clinical studies yield supportive results about the dermatological effects of the genus. However, the number of studies stating the mechanisms of actions is quite scarce. A. clypeolata Sn. grows naturally in the Thrace region of Turkiye, and is used against various health problems in folk medicine. The methanolic extract prepared from the aerial parts of the plant (ACM) was subjected to a series of tests focusing on the mechanisms of dermatological activity. First, in vitro antioxidant screening tests, including DPPH, CUPRAC, FRAP and TOAC were applied. Then, the inhibitory potential of ACM against skin-related enzymes such as collagenase, elastase and hyaluronidase was measured. For a more detailed profiling of the activity, human dermal fibroblast cells (HDFs) treated with H2O2 were given varying concentrations of ACM. WST-1 analysis was carried out for the assessment of cell viability, and DCFDA (20,70-dichlorofluorescin diacetate) method was employed for the measurement of cellular antioxidant activity. In addition, the inhibitory potentials of ACM against matrix metalloproteinase-2 and-9 enzymes, which are responsible for the degradation of extracellular matrix components in the skin, were also tested. The total phenolic (26.02 & PLUSMN; 1.04 mg GAE/g dry extract) and flavonoid (12.85 & PLUSMN; 0.69 mg QE/g dry extract) contents of ACM were calculated with the activity tests. Also, for a comprehensive quantitative analysis, LC-MS/MS analysis was carried out. All of the data gained from the mentioned tests and analysis revealed the high capacity of ACM in dermatological conditions such as the inhibitory potential enzymes associated with skin aging. Phytochemical profiling studies showed that the extract is rich in phenolic compounds, specifically chlorogenic acid, hesperidin and hyperoside. Data obtained from this study suggest that A. clypeolata may act as a natural source of skin-active ingredients. & COPY; 2023 SAAB. Published by Elsevier B.V. All rights reserved.
  • Thumbnail Image
    Conference Object
    Evaluation of Antioxidant, Anti-Inflammatory and Neuroprotective Activities and Chemical Contents of Species Used Traditionally for Inflammation in Turkey
    (Georg Thieme verlag Kg, 2023) Sen, Burcu; Ilhan, Sukran-Kubra; Erel, Buge; Gul, Zulfiye; Avsar, Timucin; Bardakci, Hilal; Diesel, Britta; Eczacılık Meslek Bilimleri Bölümü
    [No Abstract Available]