Şener, GökselAyci, Nurdan BulbulErtas, BusraKaya, Rumeysa KelesSevinc, Sevgi KocyigitAmuran, Gokce GulluErcan, FerihaCetinel, SuleEczacılık Meslek Bilimleri Bölümü2025-01-112025-01-11202401309-946910.5472/marumj.14797962-s2.0-85196144042https://doi.org/10.5472/marumj.1479796https://hdl.handle.net/20.500.14627/253Sener, Goksel/0000-0001-7444-6193; Ercan, Feriha/0000-0003-2339-5669; Akkiprik, Mustafa/0000-0002-1100-765X; Gullu Amuran, Gokce/0000-0002-2267-2110; Orun, Oya/0000-0003-1581-2207; ERTAS, BUSRA/0000-0001-8374-1098Objective: The aim of this study was to reveal the effect of apocynin (APO) on the factors involved in obesity-related endothelial dysfunction (ED) and atherosclerosis (AS). Materials and Methods: Male Wistar albino rats were divided into control (CNT), high-fat diet (HFD) and HFD+APO groups. HFD and HFD+APO groups were fed HFD for sixteen weeks. APO (25 mg/kg) was administered to the HFD+APO group for the last four weeks. The effects of APO on: AS-related metabolic parameters (triglyceride, total cholesterol, high-density lipoprotein-cholesterol, insulin and leptin), oxidative stress (OS), [ malondialdehyde, glutathione, nicotinamide adenine dinucleotide phosphate (NADPH)oxidase-2, oxidised-low-density lipoprotein (ox-LDL) and 8-hydroxy-2-deoxyguanosine], low-density lipoprotein and ox-LDL uptake potential (activin receptor-like kinase-1 and lectin-like oxidized low-density lipoprotein receptor-1, respectively), tissue inflammation inducible-nitric oxide synthase, nitric oxide), programmed cell death (terminal deoxynucleotidyl-transferase-dUTP-nick-end (alpha-smooth muscle actin), histology and ultrastructure of thoracic aorta were evaluated. Results: In obesity, APO had an ameliorative effect on metabolic parameters, OS, inflammation, ED, programmed cell death and oxLDL uptake potential, but not on foam cell formation and LDL uptake potential. Conclusion: Apocynin may improve ED and AS in obesity by suppressing OS-linked factors involved in the early stage of AS.eninfo:eu-repo/semantics/openAccessApocyninAtherosclerosisEndothelial DysfunctionOxidative StressObesityHigh-Fat DietArticleQ4372238247WOS:001240535000008