Ağalar, CananSencan, IrfanCag, YaseminKarabay, OguzKurtaran, BehiceGuclu, ErtugrulOgutlu, AzizAgalar, CananTıbbi Hizmetler ve Teknikler Bölümü2025-01-112025-01-11202272146-31232146-313110.4274/balkanmedj.galenos.2022.2021-11-622-s2.0-85133362344https://doi.org/10.4274/balkanmedj.galenos.2022.2021-11-62https://hdl.handle.net/20.500.14627/92Kuzi, Semanur/0000-0001-6496-1773; EREN-KUTSOYLU, Oya Ozlem/0000-0003-3814-0474; KARABAY, OGUZ/0000-0003-1514-1685; kul, gulnur/0000-0001-7317-3461; Unver Ulusoy, Tulay/0000-0002-0172-2326; Cag, Yasemin/0000-0002-9983-0308; Sencan, Irfan/0000-0003-0465-5090; INAL, AYSE SEZA/0000-0002-1182-7164Background: Broad-spectrum empirical antimicrobials arc frequently prescribed for patients with coronavirus disease 2019 (COVID-19) despite the lack of evidence for bacterial coinfection. Aims: We aimed to cross-sectionally determine the frequency of antibiotics use, type of antibiotics prescribed, and the factors influencing antibiotics use in hospitalized patients with COVID-19 confirmed by polymerase chain reaction. Study Design: The study was a national, multicenter, retrospective. and single-day point prevalence study. Methods: This was a national, multicenter, retrospective, and single-day point-prevalence study, conducted in the 24-h period between 00:00 and 24:00 on November 18, 2020, during the start of the second COVID-19 peak in Turkey. Results: A total of 1500 patients hospitalized with a diagnosis of COVID-19 were included in the study. The mean age +/- standard deviation of the patients was 65.0 +/- 15.5, and 56.2% (n = 843) of these patients were men. Of these hospitalized patients, 11.9% (n = 178) were undergoing invasive mechanical ventilation or ECMO. It was observed that 1118 (74.5%) patients were receiving antibiotics, of which 416 (372%) were prescribed a combination of antibiotics. In total, 71.2% of the patients had neither a clinical diagnosis nor microbiological evidence for prescribing antibiotics. In the multivariate logistic regression analysis, hospitalization in a state hospital (p < 0.001), requiring any supplemental oxygen (p = 0.005). presence of moderate/diffuse lung involvement (p < 0.001), C-reactive protein >10 ULT coefficient (p < 0.001), lymphocyte count < 800 (p = 0.007), and clinical diagnosis and/or confirmation by culture (p <0.001) were found to be independent factors associated with increased antibiotic use. Conclusion: The necessity of empirical antibiotics use in patients with COVID-19 should be reconsidered according to their clinical, imaging, and laboratory findings.eninfo:eu-repo/semantics/openAccess[No Keyword Available]ArticleQ2Q1393209217WOS:000806079300007356117051130917