Kulabaş, N.Gürboǧa, M.Özakpinar, Ö.B.Liu, J.Jakobsson, P.-J.Daniş, Ö.Küçükgüzel, I.2025-03-102025-03-1020231300-418210.55262/fabadeczacilik.13368312-s2.0-85196581992https://doi.org/10.55262/fabadeczacilik.1336831https://hdl.handle.net/20.500.14627/846Some new triazole containing acetamide derivatives 9-20 using paracetamol as starting material were synthesized, and their structures were verified by FTIR, NMR (1H and 13C) and mass spectral data. Compounds 9-20 were tested against five human cancer cell lines (lung cancer A549, chronic myelogenous leukemia K562, breast cancer MCF-7, prostate cancer PC-3, neuroblastoma SH-SY5Y cell lines) for in vitro cytotoxic activities. They were also evaluated their cytotoxic effect on mouse embryonic fibroblast cells (NIH/3T3) to define selectivity by MTT assay. Additionally, we evaluated the potential mPGES-1 and COX-1/2 inhibitory effect of twelve target compounds 9-20. While none of the synthesized compounds exhibited significant inhibition against both cancer cells and mPGES-1 as well as COX-1/2, it was determined that they were not cytotoxic against healthy cells, too. Finally, ADMET properties of newly synthesized compounds were estimated using in silico methods. © 2023 Society of Pharmaceutical Sciences of Ankara (FABAD). All rights reserved.eninfo:eu-repo/semantics/openAccess1,2,4-TriazoleCancerCox-1/2Mpges-1ParacetamolArticleN/AQ4483395410