Bulut, Z.I.Unal, E.Oksuz, S.Dogru, A.Akyol, A.Yakut, Y.2025-03-102025-03-1020250019-541310.1007/s43465-025-01350-42-s2.0-85218684486https://doi.org/10.1007/s43465-025-01350-4https://hdl.handle.net/20.500.14627/874Purpose: This study was planned to test whether the Cognitive Exercise Therapy Approach- Biopsychosocial Questionnaire (BETY-BQ) is an appropriate questionnaire in assessing the biopsychosocial status in KOA. Methods: Frequently used assessment tools, OA-specific scale The Western Ontario and McMaster Universities OA Index, the Hospital Anxiety and Depression Scale, and the Short Form-36 were utilized for the validity and responsiveness of BETY-BQ in individuals with KOA. The test–retest method, internal consistency analysis, and item analysis were used to test reliability. For the test–retest method, BETY-BQ was administered again to the same 30 individuals 1 week later. To assess the responsiveness of the BETY-BQ, individuals who underwent medical treatment were subjected to a second round of questionnaire administration after a 3-month interval. Results: Moderate to weak correlations between BETY-BQ and the other questionnaires ensued the divergent validity. According to the confirmatory factor analysis, all goodness-of-fit indices of BETY-BQ were acceptable (CMIN/df = 2.212; RMSEA = 0.080; SRMR = 0.08). Both Cronbach’s α (0.900) and ICC value (0.941) showed that the BETY-BQ has excellent reliability in the KOA population. The Bland–Altman Plot showed high agreement as all differences between the first and second BETY-BQ were found between the 95% lower and upper limits. BETY-BQ demonstrated moderate responsiveness as the effect size and standardized mean response were 0.656 and 0.566, respectively. Conclusion: A valid, reliable, responsive, multi-dimensional, and self-reported questionnaire for measuring biopsychosocial status in KOA was introduced to the use of healthcare professionals. © Indian Orthopaedics Association 2025.eninfo:eu-repo/semantics/closedAccessBiopsychosocialChronic PainFunctionHolisticOsteoarthritisValidityArticleQ4Q3