TR-Dizin İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14627/9

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Citation Count: 0
Analysis of Selected Steroid Hormones in Sea of Marmara Sediment Samples by Lc-esi/Ms-ms
(Istanbul Univ, Fac Pharmacy, 2023) Yurdun, Türkan; Yurdun, Turkan; Eczacılık Meslek Bilimleri Bölümü
Background and Aims: Sediment is the general name given to the muddy structure located at the bottom of aquatic environments such as the sea. In our study, the amounts of steroid hormones were investigated in the sediment samples taken from the Marmara Sea. According to other studies, it has been determined that the excess of the hormone load in the sediments may be an indicator of human/animal sourced pollution, as well as the negative effects of the hormones mixed in the seas with the ecological cycle on the health of humans and animals.Methods: In our study, 31 selected human/animal, plant, natural and synthetic hormone-steroids were studied using Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry (LC-ESI/MS-MS). Methanol and QuEChERS were used as extraction methods. Sediment samples were taken from a total of 27 points selected for sampling at the Marmara Sea.Results: According to the results we found, the androgens: androsterone (24.50-1718.18 ng g-1), testosterone (86.30-1600.32 ng g-1); the estrogens: mestranol (33.73-228.32 ng g-1), equilin (53.44-1232.53 ng g-1); the progestagens; pregnenolone (37.50374.76 ng g-1), progesterone (39.96-405.60 ng g-1); levonorgestrel (325.25 and 937.93 ng g-1); the fecal sterols: cholestanone (57.57-1726.32 ng g-1), coprostanol + epicoprostanol (51.43-1370.33 ng g-1); and the plant sterol; campesterol (35.30-1859.90 ng g-1) were the compounds detected.Conclusion: Estrogens and progestogens are active components of birth control pills, and cholestanone and coprostanol + epicoprostanol are steroids that are indicative of human/animal pollution. Coprostanol + epicoprostanol and cholestanone, which are indicators of fecal pollution, were detected in all sediment samples. In our study, steroid hormones were detected for the first time in Sea of Marmara sediments and possible environmental risks were evaluated.
Citation Count: 0
Bibliometric Analysis of Publications on Stigmatization in Psychiatric Nursing Literature
(Kare Publ, 2024) Dikeç, Gül; Saritas, Merve; Oban, Volkan; Hemşirelik Bölümü
Objectives: In the past two decades, the number of publications on stigma has increased in the literature. This study aimed to conduct a bibliometric analysis of publications related to stigmatization in the psychiatric nursing literature. Methods: In this study, a search was performed on the PubMed database on September 11, 2022, with the Medical Searching Terms "(Stigmatization [Title OR Abstract] OR Social Stigma [Title OR Abstract]) OR (Stigma [Title OR Abstract] OR Stereotyping [Title OR Abstract] OR Discrimination [Title OR Abstract]) AND (Psychiatric Nursing [Title OR Abstract] OR Nursing [Title OR Abstract])." Between 1990 and 2022, 10,571 studies published in English, available in full text, and published in journals indexed with SCI, SSCI, and ESCI were found. Results: The number of published articles reached the highest number in 2020, with an increase of 4.05 times in 30 years; it was determined that 92.8% of the publications were of the descriptive study, and Happell was the most productive author in this field. Frequently, articles were published in the Journal of Psychiatric and Mental Health Nursing (n=762), Journal of Psychosocial Nursing and Mental Health Services (n=550), International Journal of Mental Health Nursing (n=480), Issues in Mental Health Nursing (n=445), and Journal of Advanced Nursing (n=429). It was determined that the top five most frequently repeated keywords were humans, female, psychiatric nursing, male, and adult, respectively. Conclusion: The findings obtained from this study can provide information about the number of publications, research types, researchers, and institutions, as well as give ideas for new research strategies in psychiatric nursing literature. Establishing cooperation between institutions and authors can guide psychiatric nurses in creating projects to reduce stigma.
Citation Count: 0
The Effects of Chard Extract Against Streptozotocin-Induced Erectile Dysfunction in Rats
(Istanbul Univ, Fac Pharmacy, 2024) Şener, Göksel; Sacan, Ozlem; Kabasakal, Levent; Cetinel, Sule; Kadihasanoglu, Mustafa; Kendirci, Muammer; Sener, Goksel; Eczacılık Meslek Bilimleri Bölümü
Background and Aims: To analyze the potential therapeutic effects of chard against streptozotocin (STZ) -induced erectile dysfunction (ED) and oxidative damage in the corpus cavernousum in rats. Materials and Methods: In this study, Sprague-Dawley rats (250-300g) were allocated into groups as follows: control, diabetic, diabetic + chard, and diabetic + insulin. In order to induce diabetes, rats were given 65 mg/kg intraperitoneal streptozotocin. Chard extract was given orally at a dose 2 g/kg for 45 days beginning on 15 th days. Sixty days after STZ injection, intracavernosal pressure (ICP) was measured and rats were decapitated. Blood samples were obtained for glucose, asymmetric dimethylarginine (ADMA)levels, and lactate dehydrogenase (LDH) activity while cavernous tissues were taken to analyze luminol and lucigenin chemiluminescence (CL), malondialdehyde and glutathione and along with histological analysis. Results: The results revealed that diabetes caused significant decreases in cavernosal tissue glutathione levels, while luminol and lucigenin CL, and malondialdehyde levels were significantly elevated. Plasma glucose, ADMA levels, and LDH activity were also found to be increased in diabetic group. On the other hand, both chard extract and insulin treatment reversed these biochemical parameters significantly. Furthermore, it was found that the ICP value examined for evaluating erectile functions were lower in the diabetic group, but increased in both treatment groups which were similar to the control values. Conclusion: According to our results, chard extract, similar to insulin, reduced diabetes -induced oxidative damage in cavernosal tissue and protected erectile functions. This effects may be attributed its hypoglycemic and antioxidant properties.
Citation Count: 0
The Effects Of Panax Ginseng on Serum Oxidative Stress Following Bisphenol a Exposure
(Istanbul Univ, 2024) Ede Pazarbaşı, Seren; Şener, Göksel; Dorucu, Dogancan; Sener, Goksel; Tunali-Akbay, Tugba; Eczane Hizmetleri Bölümü; Eczacılık Meslek Bilimleri Bölümü
Objective: Bisphenol A (BPA) is a toxic compound that causes oxidative stress by disrupting antioxidant enzymes and promoting tissue lipid peroxidation. This study aimed to examine the impacts of BPA on serum oxidative stress in rats and to detect the antioxidant feature of Panax ginseng (PxG) in reducing BPA-induced oxidative stress. Materials and Methods: Wistar Albino rats (250-300 g) were divided into control, control + PxG, BPA, and BPA + PxG groups. 50 mg/kg BPA and 100 mg/g PxG were given for six weeks. Serum total antioxidant and oxidant status, lipid peroxidation, and glutathione levels were determined. Results: BPA administration increased total oxidant status and lipid peroxidation, while PxG administration to the BPA group decreased these parameters. PxG also increased total antioxidant status and glutathione levels compared to the BPA group. Conclusion: BPA was seen to cause an increase in oxidative parameters and PxG administration to restore the oxidative stress that was generated after BPA exposure, suggesting that this may help to prevent the adverse effects caused by BPA exposure.
Citation Count: 0
Evaluation of Promotion Theses of Museologists Prepared Between 1943 and 1973 in Terms of Architectural History
(Yildiz Technical Univ, Fac Architecture, 2022) Bilgen, Cigdem; Urfalioglu, Nur
Works by museologists with different occupations and titles featuring important documents are in the archive of the General Directorate of Cultural Heritage and Museums of T.R. Ministry of Culture and Tourism. Archivers recorded them at the Ministry of Culture's inventory as "promotional thesis" and organised them in 330 files from folders 1 to 34. The General Directorate of Classics and Museums demanded such theses from museologists for promotional purposes. Contents and constructs of dissertations about different fields and subjects featured important references. Therefore, these theses have a characteristic to enlarge the scale of research topics or enhance efforts leading to literature scanning for respective research subjects. Thirty-seven of 330 theses with known dates and authors included important information in architectural history and were investigated in the doctoral thesis study. Such 37 dissertations covering the period 1943-1973 were prepared considering Law on Organization of Museums and Observatories numbered 2530 enacted in TGNA on 23rd June 1934. It is the first legal arrangement in Turkish museology's history to officially register museums as separate institutions causing a leap in Turkish museology as of its effective date. With this law, guidebooks illuminating cities' architectural history written by museologists between 1930s and 1970s and published by the Board of Education and Ministry of Culture were prepared alongside promotional theses - products of Turkish museology's progress. This study illustratively evaluates promotional theses written based on law dated 1934 in architectural history. With the study of the 37 theses, written between 1943 and 1973, detection of another respective thesis in the archive and determination of the relevant legislative link and reasoning behind has gained critical importance. When we look at the selection of the topics of the promotion thesis, we see a great variety and substantiality in the subjects. Additionally, it has been targeted to inspire the researchers who have studied in the fields of the topics of respective thesis and their topics. The subjects in these archive documents are archaeological sites, single building scale, urban history studies and period studies. Within the scope of this article, one example of these topics has been selected. The thesis chosen as an example of archaeological sites is Raci Temizer's thesis entitled "Ayazmayeni Koyu Kayapinar Hoyugu Buluntulari" written in 1952. Another thesis is the subject of a single structure scale and M. Hadi Altay's thesis titled "Revan Kosku", written in 1958. The third thesis is an example of urban history studies titled "Kastamonu Eski Eserler Kilavuzu" and it was written by Ahmet Gokoglu in 1949. The last sample promotion thesis chosen as a period study belongs to the Cengiz Koseoglu. The title of the promotion thesis written in 1970 is "Maras'ta Dulkadiroglu Mimarisi". A detailed text about these theses is included in this article study. In addition, the catalogues of these four sample theses, which have been prepared in accordance with the A3 format in the excel file, have been included in the study. The differentiation of promotion theses in catalogues has been in the form of placing only selected sample pages from the text pages and turning all the images contained in the theses into one or more tables. Due to these catalogues, promotion theses have become more descriptive, and evaluations of these theses have been made in detail in many ways. Consequently, this article also emphasises the benefit of this cataloguing method applied for promotion theses. All theses, just like the other theses in the archive of Cultural Assets and Museums General Directorate, are the product of culture policies that started to be applied in the fields of historical works and museums in the Early Republic Period. As stated in the respective acts of law, the promotion of the museum officials as a result of their scientific works prepared in their workplace museums is very important. In addition, the museum officials' examining the architectural works in their theses, both in a visual and literal way is also very important in showing the significance of the contribution of this work not only to the history of architecture but also art history, restoration, archaeology and any other related fields. The Museum Officials criteria in determining the aims for selecting the topics of their theses from filling the gaps in the literature topics, contributing to the museum they work for or working in the fields of their interest or curiosity, shows not only the great contribution of the theses to the Turkish Museum History but also proves that they were prepared in a way to capture the fields of architecture and art history. This study aims to emphasise the importance of this point as well. In order for researchers and scientists to access the data in the theses and use this data in their own studies, it is necessary to reveal these theses contained in the ministry archive.
Citation Count: 1
Investigation of the Protective and Therapeutic Efficacy of myrtus Communis Extract in Aluminum Chloride and Dgalactose-Induced Alzheimer's Disease in Rats
(Marmara Univ, 2022) Şener, Göksel; Sen, Ali; Cevik, Ozge; Kadioclu-Yaman, Beril; Ertas, Biiva; Yildiz, Sila; Sener, Goksel; Eczacılık Meslek Bilimleri Bölümü
This study investigated the possible protective and therapeutic effects of Myrtus communis subsp. communis ethanol extract (MC) in aluminum chloride (AlCl3) and D-galactose (D-Gal) induced Alzheimer's disease in rats. MC was orally given to rats as a protective treatment for 90 days and, in other two groups starting from the 60th day MC (100-200 mg/kg) was administered, concomitantly with AlCl3 and D-Gal. Learning and memory functions were evaluated by the behavioral tests. Biological activities of MC treatment were examined in hippocampal tissues by ELISA tests. D-Gal and AlCl3-treated rats showed increased amyloid beta (A ss) and 8-hydroxy-2-deoxyguanosine (8OHdG) levels, acetylcholinesterase activity and decreased neprilysin, Na+-K+ATPase and SOD levels in parallel with a decrease in Novel Object Recognition Test, Morris Water Maze and Passive Avoidance Test scores. On the other hand, MC administration reversed the behavioral impairments and improved learning and memory. Moreover, MC treatment decreased A ss and 8-OHdG levels and acetylcholinesterase activity and increased neprilysin levels, Na+-K+ATPase and SOD levels. Our results suggest that MC has beneficial effects on cognitive and neuronal functions through its anticholinesterase and antioxidant properties.
Citation Count: 0
Nonviolent Communication in Lifelong Education
(Hacettepe Univ, 2023) Baban, Ece; Doğan Erdinç, Ece; Halkla İlişkiler ve Reklamcılık Bölümü
In today's world, the increase of othering and xenophobia with acts of violence, along with the changes that consume resources due to climate changes such as wars, irregular migration movements, famine and thirst, are an important necessity for understanding nonviolent communication and its application in the field of lifelong education. This requirement brought the problem of "adult education" to the agenda and accelerated the studies on the lifelong learning approach. In addition, key messages developed by UNESCO and the European Commission defined the characteristics that the lifelong learning approach should have. Within the scope of the study, the concept of nonviolent communication explained, and the "Make a Gesture Your Opponent" campaign, which includes nonviolent communication training for Turkey Football Federation first league teams, examined. Within the scope of the study, the "Make a Gesture to Your Opponent" campaign was determined as a case study. Accordingly, the official website of the campaign was examined. As a result of the analysis carried out in line with the key messages, the nonviolent communication approach that the "Make a Gesture Your Opponent" project wanted to instill in its participants shows how important education is in all areas of life.
Citation Count: 0
Panax Ginseng Extract Ameliorates Methotrexate-Induced Multi-Organ Damage Via the Regulation of Oxidative Stress
(Marmara Univ, 2023) Ede Pazarbaşı, Seren; Yılmaz Karaoğlu, Sümeyye; Şener, Göksel; Tunali-Akbay, Tugba; Karakaya-Cimen, Fatma Bedia; Ercan, Feriha; Sener, Goksel; Eczane Hizmetleri Bölümü; Eczacılık Meslek Bilimleri Bölümü
Oxidative damage plays an important role in organ toxicities caused by methotrexate (MTX). This study aimed to determine the antioxidant effects of Panax ginseng (PxG) extract against MTX-induced liver, lung, ileum and kidney damage. Twenty-four Sprague Dawley male rats (weight 250-300 g) were used in the study. The animals were randomly separated into three groups: a) Control, b) MTX-treated (MTX) and c) MTX+PxG-treated (MTX+PxG) groups. MTX was administered intraperitoneally at 20 mg/kg, as a single dose to MTX and MTX+PxG groups. PxG was administered orally at 100 mg/kg to the MTX+PxG group for five days. Saline was given to the control and MTX groups for 5 days. At the end of the experiment, liver, lung, ileum, and kidney samples were obtained. Malondialdehyde (MDA) and glutathione (GSH) levels, superoxide dismutase (SOD), glutathione-S-transferase (GST) and tissue factor (TF) activities were determined in all tissues. In addition, histological examinations were done through light microscopy. GraphPad Prism 5v. was used for statistics, and p<0.05 were considered significant. Administration of MTX caused severe injury in tissues. Findings showed that MDA level, SOD, and GST activities were significantly normalized in the MTX+PxG group compared to the control group. A significant reduction in GSH level observed in the MTX group was reversed with PxG administration In addition, TF activity and total protein levels were found to be impaired in the MTX group, but TF activity was significantly improved in liver and lung tissues and total protein level was significantly reversed in lung and ileum in MTX+PxG group. The results of histological examinations showed that MTX-induced damage was ameliorated with the PxG administration. In conclusion, this study shows that Panax ginseng, thanks to its antioxidant properties, reversed MTX-induced tissue damage and therefore may be beneficial against side effects in patients undergoing chemotherapy.
Citation Count: 0
Space as a Source of Alienation in the Context of Migration Debates
(Yildiz Technical Univ, Fac Architecture, 2022) Ulubay, Serhat; Onal, Feride
Migration is one of the main agenda items of the time we live in. Migration mobility, which is defined as an act of displacement in its basic meaning corresponds to a process affecting many dynamics. It does not seem possible to make an overarching immigration definition due to the reasons for its emergence, the effect it creates on the social structure and the difference in its results. The phenomenon of immigration existing in the literature with definitions closer to its essential sense such as 'spatial mobility', 'act of displacement', 'transition from one place to another with the intention of settlement' does not contain the content of an absolute border crossing action. Crossing a border does not end the act of migration, but immigrants encounter ethnic, religious, social, class and many other thresholds and borders. For this reason, migration is not just an act of displacement. Immigrants migrate to places, cultures, social structures, life and many other aspects of new geographies. Social elements and spaces established with daily lives are one of the thresholds faced by the immigrant. Immigrants are stuck between the places in their geographies and the places and lifestyles in their new places where they came through immigration. This contrast manifests itself as soon as they step into a new geography and this situation transforms into an element of oppression for immigrants. The migration does not only correspond to the loss of physical spaces, but also to the dissipation of all social and daily life. For that reason, Arent, Heidegger and Blanchot define migrations of the current time period is independent of a physical displacement, alienation from the social and daily life acts to which one belongs and estrangement of the individual from his own essence. Alienation of one's own self, identity and sociality, drags them into an everlasting migration. For this reason, Blanchot emphasises that immigration starts as soon as the immigrant gets used to the places where he/she migrates, not when he/she fails to get used to the places. It is worth remembering that the space cited here has abstract content as well as concrete construction activity. Space according to Lefebvre exists as a product of the cultural, social and historical acts of societies. For this reason, it is specific to a community. It incorporates not only a concreteness, but also the mentality containing the traces of communities. Space represents a critical threshold in debates about immigration. For immigrants, space is both the grounds fin- establishing a sense of belonging and preserving their own identity, as well as the source of alienation and mental migration. This contrast is discussed in the study through Derrida's "hospitality" statement and the concepts of spatial memory and belonging. Immigrant according to Derrida, encounters a sovereign power defining itself as the owner of the place, in other words, the host, in the geography where he migrated. The host offers a place to the immigrant, whom he/she sees as a guest, and hosts him/her in his home. In fact, the landlord defines where, how and in what way he or she will live, together with the space and draws limits to him/ her. That he/she presents his/her way of life to the immigrant as if it were a rule that he/she must abide by. This style of presentation is a kind of imposition, because it doesn't contain any preference option in it: "I host you in my home. Welcome to my home, save to adhere my language, tradition, lifestyle, laws and rules". This language of life that the immigrant does not recognise and is not familiar with, is an act of mental 'violence perpetrated against him/her. This act of violence takes place through space. Although the immigrant loses his/her place by experiencing a physical migration, he/she brings all the acts of his social and daily life with him/her through his memory. These acts kept in the memory, stands out as the founding elements of the space in the new lands. Immigrants attempt to create their own spaces and lives through their memories instead of venues and lifestyles offered to them. For this reason, space is also the opposite of mental migration and alienation as the preservation of ego and identity. The space, in the migration actions that took place in the current time period, on one hand, is the main actor of eternal immigration and on the other hand protecting identity. The immigrant is stuck between the space offered to him/her and his/her actions and spatial memory in the new lands he/she has come from. The study aims to examine the situation of the immigrant, to question the source of alienation and (main) migration over this sense incorporated by the space.

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